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AP1189 or placebo is dosed once daily for 4 weeks in parallel with the initiation of a treatment with the disease-modulating, anti-rheumatic drug methotrexate (MTX). The full study consisting of

23/09/20. 3 items of Media 14 Aug 2018 To study the signaling profile, we monitored cAMP accumulation and an ERK1/ 2-biased melanocortin small molecule (AP1189) that presents 13. jun 2018 Danish biotech company Synact Pharma did not get the results the company expected with its main asset AP1189 in a phase 1 study. 9 Jun 2010 ongoing phase 2a studies, and the initiation of a phase 2b study, for AP214. Action Pharma develops AP1189 for oral treatment of systemic In order to better assess the mechanism of action of the active study drug AP1189 , AP1189 is compared to an inactive substance (placebo). Which treatment the 6 Feb 2020 In addition, the pan-MC agonist AP214 and the biased AP1189 small molecule also display anti-arthritic properties. In the present study, we 2021-03-18 07:04:53 SynAct has initiated dosing in part 2 of the clinical Phase II study with AP1189 in Covid-19 infected patients UK version 0,00% | 6,29 MSEK http://www.who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2020-001049-38-FI, 2020 | added to CENTRAL: 31 March 2021 | 2021 Issue 3.

Ap1189 study

SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). SynAct Pharma investigates the possibility of developing its clinical anti-inflammatory lead candidate drug AP1189 as an additional therapy in hospitalized patients with COVID-19 infection, to prevent Acute Respiratory Distress Syndrome (ARDS). AP1189 is developed as an add-on to MTX to reduce inflammation and support resolution ➜attenuate symptoms and decrease time to resolution ➜reduce need for second line treatment and/or reduce MTX dose 12 AP1189 In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inhibitor or Angiotensin-2 receptor antagonists in a once-daily dose regimen for four weeks with the primary purpose to show treatment effect on urinary protein excretion relative to pre-treatment levels and placebo. AP1189 or placebo is dosed once daily for 4 weeks in parallel with the initiation of a treatment with the disease-modulating, anti-rheumatic drug methotrexate (MTX). The full study consisting of In this study, we characterize the small molecule AP1189 as a biased agonist at receptors MC1 and MC3. AP1189 is developed as an add-on to MTX to reduce inflammation and support resolution ➜attenuate symptoms and decrease time to resolution ➜reduce need for second line treatment and/or reduce MTX dose 12 AP1189 SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). SynAct Pharma has announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS).

AP1189 or Placebo is given once daily for 4 weeks in parallel with the initiation of treatment with the disease modulating anti-rheumatic drug, methotrexate.

En tydlig utvecklingsplan för AP1189 stärker förhandlingspositionen - Synact expects to present interim data from its Phase IIa study in rheumatoid arthritis

Den planerade fas II-studien med AP1189 kommer att utformas som en randomiserad dubbelblindad placebokontrollerad studie, där säkerheten, Den 29 juni initierade SynAct en klinisk fas II-studie med läkemedelskandidat AP1189 på idiopatisk membranös nefropatipatienter med nefrotiskt syndrom. Den 15 juli meddelade SynAct framsteg i den andra dosnivån (100 mg) i del 1 av den kliniska fas II-studien med AP1189 hos patienter med reumatoid artrit och hög sjukdomsaktivitet på kliniker i Danmark och Sverige.

Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a A study also demonstrate how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved

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The study is designed as a placebo-controlled double-blind multicenter study with a 2:1 randomization ratio of once-daily dosing of AP1189 vs placebo in RA patients referred to rheumatological departments due to uncontrolled disease activity defined as clinical disease activity index (CDAI) higher than 22. A double-blind study for patients with idiopathic membranous nephropathy in treatment with ACE inhibor or angiotensin II receptor blockers. The trial will take place in hospitals in Europe. To better assess the mechanism of action of AP1189, the compound is compared to an inactive substance (placebo). SynAct Pharma AB ("SynAct") today announced that dosing in the second part of the exploratory clinical Phase 2 study with AP1189 in Covid-19 patients conducted under the RESOVIR collaboration has been initiated following completion of the initial open label part of study.
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SynAct Pharma Initiates Phase II Study with AP1189 for the Treatment of ARDS in COVID-19 Patients Wed, Sep 23, 2020 08:28 CET. SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress 2020-07-15 SynAct Pharma has announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). SynAct Pharma AB ("SynAct") today announced that the company has initiated a Phase II clinical study with the AP1189 compound in idiopathic membranous nephropathy patients with Nephrotic Syndrome.. In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inhibitor or Angiotensin-2 receptor antagonists in a once-daily dose 2020-09-03 In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inh ibitor or A ngiotensin-2 receptor antagonists in a once-daily dose regimen for four weeks with the primary purpose to show treatment effect on urinary protein excretion relative to pre-treatment levels and placebo. The patients will be dosed with either 100 mg As AP1189 does not induce the treatment limiting side effects seen following ACTH treatment, the AP1189 compound could be a very attractive new treatment option in NS. We therefore consider it a major milestone in the development of the compound that we now have a Phase II clinical study up running in the iMN patients says Thomas Jonassen, CSO in SynAct Pharma.

AP1189 -DEVELOPMENT OVERVIEW Start ofclinicalphaseI study (healthy) SynAct Pharma Initiates Phase II Study with AP1189 for the Treatment of ARDS in COVID-19 Patients Wed, Sep 23, 2020 08:28 CET. SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress 2021-03-18 · SynAct Pharma AB ("SynAct") today announced that dosing in the second part of the exploratory clinical Phase 2 study with AP1189 in Covid-19 patients conducted under the RESOVIR collaboration has been initiated following completion of the initial open label part of study. The second part is a randomized double-blind placebo-controlled study in 56 Covid-19 patients at clinical sites at In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inhibitor or Angiotensin-2 receptor antagonists in a once-daily dose regimen for four weeks with the primary purpose to show treatment effect on urinary protein excretion relative to pre-treatment levels and placebo. SynAct Pharma Initiates Phase II Study with AP1189 for the Treatment of ARDS in COVID-19 Patients SynAct Pharma "SynAct's primary focus is to rapidly determine the safety and efficacy of AP1189 as a potential treatment for COVID-19.
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SynAct Pharma has announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS).

Det säger vd Jeppe Øvlesen och forskningschef Thomas Möjligheten för AP1189 att bli en ny behandlingsmetod inom resolutionsterapi bedömer vi som lovande och med vår pågående studie inom RA beräknar vi kunna erhålla Proof-of-Concept för AP1189 under Q1 2021 samt rapportera interimsresultat i slutet av det första kvartalet 2020. SynAct Pharma initierar fas II-studie med AP1189 för behandling av ARDS i COVID-19-patienter SynAct Pharma AB ("SynAct Pharma") meddelade i dag att bolaget har inlett en klinisk fas II-studie för att utvärdera säkerhet och effekt av AP1189 hos vuxna som diagnostiserats med COVID-19 och med tidiga tecken på akut andningssviktsyndrom (Acute Respiratory Distress Syndrome, ARDS). The study is designed as a placebo-controlled double-blind multicenter study with a 2:1 randomization ratio of once-daily dosing of AP1189 vs placebo in RA patients referred to rheumatological departments due to uncontrolled disease activity defined as clinical disease activity index (CDAI) higher than 22.

A double blind trial in two parts in people with active newly discovered rheumatoid arthritis. The experiment takes place in several hospitals. In order to better assess the mechanism of action of the active study drug AP1189, AP1189 is compared to an inactive substance (placebo).

2020 — Även om Covid-19 har skapat ett nytt indikationsutrymme för AP1189, to start a study very soon« — Jeppe Øvlesen, CEO SynAct Pharma. M. C., Polizzi, R. B., Teixeira, M. M. & Mota, C. R., 1 maj 2021, I: Water Research. SynAct Pharma Initiates Phase II Study with AP1189 for the Treatment of 1 okt.

In the study, AP1189 will be examined as a potentially additional therapy for patients with idiopathic membranous nephropathy who have nephrotic syndrome. A Study of the Safety, Tolerability and Efficacy of Treatment With AP1189 in Early RA Patients With Active Joint Disease (SynAct-CS002) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.